Thematic Lines

LS4FUTURE‘s research addresses four key Thematic Lines (TL), which function in a knowledge-based symbiotic relationship.

TL1 – FROM MOLECULES TO ECOSYSTEMS

TL2 – MECHANISMS OF DISEASE FOR PRECISION MEDICINE

TL3 – ADVANCED THERAPEUTICS: DISCOVERY AND DEVELOPMENT

TL4 – BIOTECHNOLOGY FOR A SUSTAINABLE WORLD

New knowledge in life-sciences to power other TLs
Digital & quantitative biology
Molecules, cells, organisms & ecosystems
Physiology, ecology & evolution

Active & healthy aging
Personalised medicine & biomarkers
Infectious & chronic diseases
Novel therapies

Design & development of biopharmaceutics & drugs
Cell technology for pre-clinical research
Engineering processes for biopharmaceuticals

Biomatearials & green chemistry
Plant sciences for food security
Renewable resources for energy & environment
Food safety
Synthetic biology for catalisys & remediation

Thematic lines

LS4FUTURE‘s research addresses four key Thematic Lines (TL), which function in a knowledge-based symbiotic relationship.

TL1 – FROM MOLECULES TO ECOSYSTEMS

New knowledge in life-sciences to power other TLs
Digital & quantitative biology
Molecules, cells, organisms & ecosystems
Physiology, ecology & evolution

TL2 – MECHANISMS OF DISEASE FOR PRECISION MEDICINE

Active & healthy aging
Personalised medicine & biomarkers
Infectious & chronic diseases
Novel therapies

TL3 – ADVANCED THERAPEUTICS: DISCOVERY AND DEVELOPMENT

Design & development of biopharmaceutics & drugs
Cell technology for pre-clinical research
Engineering processes for biopharmaceuticals

TL4 – BIOTECHNOLOGY FOR A SUSTAINABLE WORLD

Biomatearials & green chemistry
Plant sciences for food security
Renewable resources for energy & environment
Food safety
Synthetic biology for catalisys & remediation

FROM MOLECULES TO ECOSYSTEMS

Coordinators

Catarina Homem (NMS)
Ricardo Henriques (ITQB NOVA)

1 2 3 4

TL1 aims to pave the way to a healthier planet and society by producing new concepts and ground-breaking findings in life sciences at different scales of space and time, from molecules to ecosystems.

We anticipate solutions to future crises through long-term discovery-driven research, studying the molecular building blocks of living systems in a multidisciplinary approach to determine their structure, mechanisms of action, how they are regulated, and how they interact to achieve their physiological role.

By taking advantage of state-of-the-art facilities, we strive to understand the molecular mechanisms of biological processes, and how they may be manipulated through different stimuli, to explore their potential for therapeutic actions or biotechnological applications.

MECHANISMS OF DISEASE FOR PRECISION MEDICINE

Coordinators

Hugo Vicente Miranda (NMS)

José Cabeçadas (IPOLFG)

Raquel Sá-Leão (ITQB NOVA)

1 2 3

TL2 aims to understand pathophysiological mechanisms and develop a research and innovation strategy focused on technological solutions for health challenges that have a major impact on quality of life.

Through objective clinical and translational research, we keep up with a changing perception of disease, as increasingly personal and age-specific. We aim to bridge the gap between fundamental research and experimental medicine, as well as between experimental medicine and health applications.

Our main focus is:

Cancer
Neurological and Vision disorders
Metabolic and Inflammatory disfunctions
Emerging Microbial Infections.

In TL2, we will develop a Translation Enabler Programme (TEP) – a combination of tools designed to support the translation of new discoveries into heath solutions and bridge the divide from discovery to delivery.

ADVANCED THERAPEUTICS: DISCOVERY AND DEVELOPMENT

Coordinators

Diana Lousa (ITQB)
Tiago Bandeiras (iBET)

1 2 3 4 5

TL3 aims to create opportunities for industrial innovation and economic development and generate knowledge on molecular biosciences and technologies.

It works on three major research areas:

Biopharmaceuticals & Drugs: from design to development;
Advancing Cell Technology for pre-clinical research;
Engineering processes for Biopharmaceuticals.

We combine expertise from molecular, cell, structural and computational biology to mathematical modelling, engineering and clinical manufacturing.

Some of its researchers work in the scope of established R&D contracts with relevant pharmaceutical companies, while others are directed to more fundamental research.

BIOTECHNOLOGY FOR A SUSTAINABLE WORLD

Coordinators

Nelson Saibo (ITQB NOVA)
Teresa Serra (iBET)

1 2 3

TL4 aims to pave the way to a more innovative, resource efficient and competitive society that reconciles food security and safety with the sustainable use of renewable resources for industrial purposes.

We intend to strengthen the national research capacity in the areas of Plant Biology and Biotechnology, Food Safety and Security, Sustainable Chemistry and Industrial Biotechnology, while also providing a platform to train human resources for these areas.

Ultimately, we aim to support knowledge translation to the economic system to ensure food security, safety, authenticity, and nutritional quality in a climate change scenario, reducing dependence on non-renewable resources and improving soil and water quality.

This interdisciplinarity, combined with our expertise, and state-of-the-art analytical and bioinformatics technology, provides a platform for addressing critical societal challenges and contributing with innovative solutions.

The Associate Laboratory LS4FUTURE is supported by Fundação para a Ciência e a Tecnologia (FCT, Portugal) through the funding LA/P/0087/2020 (DOI 10.54499/LA/P/0087/2020).

The Associated Laboratory LS4FUTURE is supported by Fundação para a Ciência e a Tecnologia (FCT, Portugal) through the funding LA/P/0087/2020.